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KMID : 0978920100110020197
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Korean Journal of Clinical Geriatrics
2010 Volume.11 No. 2 p.197 ~ p.200
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Anti-GQ1b IgG Antibody Syndrome Presenting as Pure Complete Ophthalmoplegia without Ataxia
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Cho A-Ra
Song In-Uk
Maeng Lee-So
Chung Sung-Woo
Kim Sung-Man
Kim Young-Do
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Abstract
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Immunoglobulin G (IgG) anti-GQ1b antibody is closely associated with acute paresis with extraocular muscles. Anti-GQ1b antibody has been found in Miller-Fisher syndrome, Guillain-Barre syndrome with
ophthalmoplegia, Bickerstaff brainstem encephalitis, and acute ophthalmoplegia without ataxia. Therefore, ophthalmoplegia associated with anti-GQ1b antibody should be considered in the differential
diagnosis of acute or subacute ophthalmoplegia. However, few studies described anti-GQ1b antibody-associated acute ophthalmoplegia without ataxia. We describe a patient who presented with bilateral pure complete opthalmoplegia with ptosis. The patient had significant elevation of anti-GQ1bIg G antibody titer without other neurological abnormalities.
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KEYWORD
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Pure ophthalmoplegia, Anti-GQ1b antibody
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